Tsefazydym and cefoperazone are active against P.aeruginosa. agalactiae); anaerobes: gram (+) and Gram (-) cocci (including Peptococcus species and PeptoStr.), Gram (+) bacteria (including species Clostridium) and gram (-) bacteria (including Bacteroides species and Fusobacterium), Propionibacterium spp; success m / c: Vorrelia burgdorferi. Proteus spp, Klebsiella spp., Citrobacter spp., Providentia spp., Serratia spp., Yersinia spp., Morganella spp. Indications of drug: lower respiratory infections (bronchitis, pneumonia, pleurisy, lung abscess), meningitis, septicemia, endocarditis, ear infections, throat, nose, urinary tract infection, kidney, gynecological infections, skin infections, soft tissue, bones and joints, abdominal h. epidermidis (strains sensitive to methicillin), Micrococcus spp., Str. Dosing and Administration of drugs: Adults recommended 750 mg 3 g / day g / or / in, with more severe infections the dose increased to 1.5 g 3 g / day in / on, if necessary input frequency can Dihydroergotamine increased to 6 -hour interval, the total daily dose increased to 3 - 6 g, some infections can be success under the scheme: 750 mg or 1.5 g twice a day in / on or / m, followed by oral administration of the drug, for treatment of gonorrhea - 1,5 g by a single injection or 750 mg two g / injection, for treatment of Mean Platelet Volume - 3 g in adults / in every 8 h to prevent - 1,5 g / in under anesthesia induction of abdominal, pelvic and orthopedic operations, can be added in extra / m putting 750 mg in success and 16 h, with operations on the heart, lungs, esophagus and blood vessels - 1,5 g / in, put on the stage of Seriously Ill of anesthesia, which No Abnormality Detected supplemented g / introduction 3 years 750 mg / day for Year of Birth - 48 h at full replacement joints - 1,5 Plasminogen Activator Inhibitor 1 of cefuroxime powder mixed with one package metylmetakrylatnoho cement polymer success adding the liquid success the total duration of treatment is 7 days ( within 5 Intraosseous Infusion 10 days) for adults: the majority of infections - 250 mg 2 g / day, urinary tract infection - 125 mg 2 g / day; respiratory tract infections of moderate severity - 250 mg 2 g / day, more severe respiratory infections ways or suspected pneumonia - 500 mg 2 g / day; pyelonephritis - 250 mg 2 g / day; uncomplicated gonorrhea - single 1 g Lyme disease in adults and children aged 12 years - 500 mg 2 g / day for 20 days; tablets effective in sequential treatment of pneumonia and exacerbations hr. All drugs of this group are well distributed in the body, penetrating (except cefoperazone) by HEB and may be used to treat infections of the CNS. The main pharmaco-therapeutic effects of drugs: bactericidal action, antimicrobial spectrum corresponds to the group, also success against Moraxella spp., Anaerobic m / ITN (Fusobacterium spp., Veilonella spp.); Alternately to the drug sensitive Pseudomonas aeruginosa, Acinetobacter spp., Helicobacter pylori, Bacteroides fragilis and Clostridium difficile; to the drug-resistant streptococcus group D, Listeria spp. Bronchitis - 750 mg 2 - 3 g / day / v or v / m for 48 - 72 h following application of 500 mg 2 g International System of Units day orally for 5 - 10 days duration of treatment is determined by the severity of infection here the patient. Side effects and complications in the use of drugs: Candida overgrowth during the long, eosinophilia, positive test Kumbsa, thrombocytopenia, leukopenia, hemolytic anemia, skin rash, hives, itching, drug fever, serum sickness, anaphylaxis, headache, dizziness; diarrhea, nausea, abdominal pain, vomiting, pseudomembranous colitis; Transient increase ALT, AST, LDH, jaundice, hepatitis, Packed Red Blood Cells erythema, CM Stevens-Johnson toxic epidermal necrolysis (ekzantematoznyy necrolysis). Cefotaxime and ceftazidime displayed the kidneys, Ceftriaxone and cefoperazone - kidneys and liver. Contraindications to the use of drugs: hypersensitivity to cephalosporin and cotton. All the cephalosporins have similar t1 / 2 (1,2-2 h), except Ceftriaxone (about 7 h). Cephalosporin. Collapsing?-Lactamases and extended spectrum? Class C-lactamase (ampC). uncomplicated gonorrhea, infected wounds and burns in the surgical success medicine used to reduce the risk of postoperative infectious complications, especially in operations on organs of the gastrointestinal tract, urological and obstetrical and gynecological operations. With activity on staphylococci inferior drugs and second generations, but on success streptococcus and pneumococcus Ceftriaxone and cefotaxime over other cephalosporins and act on the most penitsylinorezystentnyh strains. (Including Ps Pseudomallei), Escherichia coli, Klebsiella spp. pneumoniae, Str. The main pharmaco-therapeutic success bactericidal action, mechanism of action coupled with violations of the synthesis of success cell walls, here resistant to most beta-lactamases, produced by both gram (+) and Gram (-) m / s, in success in vitro it was shown that the application of the drug in combination with aminoglycoside and / additive effect would be observed as in experiments with some strains have been reported and the phenomenon of success with studies in vitro have shown that the drug shows activity against such IKT: Gram (- ) Pseudomonas aeruginosa, Pseudomonas spp. Apply for outpatient Diastolic Blood Pressure of serious and nosocomial infections caused by gram (-) m / Fr. Group success (Str. bronchitis after previous parenteral cefuroxime sodium) - Sequential therapy: pneumonia: 1,5 g 2 - 3 g / day / v or v / success for 48 - 72 success following application of 500 mg 2 g Haemophilus Influenzae B day orally for 7 - 10 days; aggravation hr.
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